G-Protein β3 Subunit Gene ( GNB3 ) Variant in Causation of Essential Hypertension
نویسندگان
چکیده
منابع مشابه
G protein beta3 subunit variant and essential hypertension in Japanese.
Enhanced G protein activation has been implicated to underlie the increased sodium-proton transport in blood cells, an impaired characteristic observed in 30% to 50% of patients with essential hypertension. Recently, significant association between a C825T polymorphism of the gene encoding the G protein beta3 subunit and hypertension was demonstrated in a white population, together with the fin...
متن کاملPrediction of the Risk for Essential Hypertension among Carriers of C825T Genetic Polymorphism of G Protein β3 (GNB3) Gene
BACKGROUND The guanine nucleotide-binding protein beta polypeptide 3 (GNB3) 825T allele encodes a product that enhances the activation of heterotrimeric G proteins, which is associated with the occurrence of the splice variant Gβ3 s that could play a role in vascular reactivity and hyperproliferation of smooth muscle cells, that makes such proteins attractive candidate gene products for suscept...
متن کاملgenetic susceptibility of angiotensin-i converting enzyme and g-protein β3-subunit gene polymorphisms to essential hypertension
essential hypertension (eh) accounts for 90-95% of hypertension cases. eh, as a progressive cardiovascular syndrome arising from complex and interrelated etiologies, results from combined and interactive effects of genetic and environmental factors. the objective was to investigate the ace i/d and gnb3 c825t polymorphisms and both genotypes combined with seeking gene-gene interactions to furthe...
متن کاملG-Protein b3 Subunit Gene Variant and Left Ventricular Hypertrophy in Essential Hypertension
A functional genetic variant consisting of a C825T substitution in the GNB3 gene, encoding for the G-protein b3 subunit, has been associated with enhanced G-protein activation and cell growth. The aim of the study was to investigate the association of this polymorphism with left ventricular hypertrophy (LVH) in a sample of patients with essential hypertension. Left ventricular mass was assessed...
متن کاملG-Protein beta(3) subunit gene variant and left ventricular hypertrophy in essential hypertension.
A functional genetic variant consisting of a C825T substitution in the GNB3 gene, encoding for the G-protein beta(3) subunit, has been associated with enhanced G-protein activation and cell growth. The aim of the study was to investigate the association of this polymorphism with left ventricular hypertrophy (LVH) in a sample of patients with essential hypertension. Left ventricular mass was ass...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1998
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.32.6.1094